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Sildenafil Oral Jelly
Kamagra Oral Jelly

  • Sildenafil Oral Jelly
  • ED015
  • In Stock

Premium High Quality Product & Original Active Substance!

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   Manufacturer's Suggested Retail Price (MSRP) per sachet is $8.80 ! Buying from us will save you at least 45.34%

Package per sachet Price SAVINGS BONUS Order
100mg/5g * 7 sachets
$4.81 $33.67 $0.00
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg/5g * 14 sachets
$4.49 $62.86 $4.48
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg/5g * 21 sachets
$3.83 $80.43 $20.58
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg/5g * 28 sachets
$3.58 $100.24 $34.44
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg/5g * 35 sachets
$3.38 $118.30 $50.05
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg/5g * 42 sachets
$3.18 $133.56 $68.46
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount
100mg/5g * 49 sachets
$3.09 $151.41 $84.28
+ SILVER BONUS
SILVER BONUS
for orders under $300
►Package delivery insurance
►Next orders 10% discount

Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.

For the treatment of erectile dysfunction and to relieve symptoms of pulmonary arterial hypertension (PAH).

Kamagra Oral Jelly is offered as fruit-flavored gel sachets packed in bags. The active substance in a liquid form is better absorbed, it is easier transferred, it starts to act faster. And, also, this medicine can be bought in 7 different flavors and, furthermore, it is rather cheap. You can take it without water. It is enough to tear off the corner of the bag and eat its contents. The active substance helps to achieve an erection, and fruit flavor improves mood.

Erections are controlled by the parasympathetic nervous system. Upon sexual stimulation, a decrease in vascular resistance is mediated by acetylcholine and nitric oxide resulting in vasodilation. The hemodynamic mechanism of an erection is comprised of five stages. During the latent stage, arterial and carvernous smooth muscle relaxation occurs. Vasodilation results in high levels of blood flow causing the penis to grow to its full size. This stage is called tumescence.

During the full-erection stage, blood flow fills penis sinusoids and outflow is restricted. This is followed by the rigid-erection phase during which the cavernous muscles contract causing the penis to become rigid. Little blood flow occurs during this stage. During the final stage, detumescence, the cavernous muscles relax and blood flows out of the penis. Erectile dysfunction may occur when there is insufficient blood supply to the penis or when the penis is unable to prevent outflow of blood from the penis.

Sildenafil is a specific inhibitor of PDE5, an enzyme responsible for the breakdown of cGMP to 5’-GMP. Increased levels of cGMP stimulate vasodilation and facilitate the generation and maintenance of erections. These vasodilatory effects also help decrease symptoms of PAH. Sildenfail also exhibits some activity against PDE6 (10 times less potentcy compared to PDE5), a PDE isoform found predmoninantly in the retina. This activity is responsible for the blue tinged vision experienced by users of sildenafil.

Sildenafil inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle.

This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by sildenafil enhances erectile function by increasing the amount of cGMP.

Metabolism: Sildenafil appears to be completely metabolized in the liver to 16 metabolites. Its metabolism is mediated mainly by cytochrome P450 microsomal isozymes 3A4 (major route) and 2C9 (minor route). The major circulating metabolite, N-demethylated metabolite, has PDE selectivity similar to the parent drug and ~50% of its in vitro potency. The N-demethylated metabolite is further metabolized to an N-dealkylated N,N-de-ethylated metabolite. Sildenafil also undergoes N-dealkylation followed by N-demethylation of the piperazine ring.

Absorption: >90% absorbed with ~40% reaching systemic circulation unchanged following first-pass metabolism

Route of elimination: Sildenafil is cleared predominantly by the CYP3A (major route) and cytochrome P450 2C9 (CYP2C9, minor route) hepatic microsomal isoenzymes. After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (approximately 80% of the administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose).

Half life: 4 hours

All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Sildenafil.

Tell your doctor or pharmacist if you have any medical conditions.

Common sildenafil side effects may include: flushing (warmth, redness, or tingly feeling), headache, dizziness, abnormal vision (blurred vision, changes in color vision), runny or stuffy nose, nosebleeds, sleep problems (insomnia), muscle pain, back pain or upset stomach.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Karl
26/Jul/2024

Hi. I am 42 years old. 2 years ago I was promoted to a senior management position. The extra stress at work was all too much and this has contributed to my ability to maintain an adequate erection for sex. I spoke to my Doctor and he suggested "Kamagra Oral Jelly" for my problem. Purchased it online as it was cheaper than at my local pharmacy. It takes around 40 minutes to work and is worth the wait and the money! I find the effects of this medicine lasts for around 12 hours and is best taken without alcohol and on an empty stomach. The first three times I used Kamagra Oral Jelly, there were the side effects of a stuffy nose, some minor heartburn and diarrhea the next day. By the fourth sachet the side effects were all but gone! My wife is not aware that I take Kamagra Oral Jelly and she comments how good our sex has become. Thanks.

Denis
29/Dec/2023

I'm 66 years old, I have suffered from ED for almost 20 years but when I first took 1 sachet x 100mg of Kamagra Oral Jelly it was like I was in my 20' again. The amazing but true thing is that I'm able to get a full erection 2 nights in a row after one dose. All I can say is great stuff.

Matty
21/Oct/2023

Suffer from ED due to coronary artery disease and take a beta blocker. I tried the Kamagra Oral Jelly with success. Very minimal side effect, only for a few minutes when first taken. No real problems. Have not had erections like this in many years. A great med. for all guys with erection trouble.

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